Charles' parents emigrated to Canada at some time before 1893. Whilst there, they lost their children to a fever which was quite possibly measles. Charlton was born in Canada and the only one of their children to survive and to return to England with them in around 1899.
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I believe this is Charlton Wykes aged 8 and his family in 1901, living at Plumstead.
Charlton Wykes 45 Kent Erith London Plumstead Drammer R ...
Eliza Wykes 39 London Islington London Plumstead
Charlton Wykes 8 Canada London Plumstead
Edwin Wykes 4 London Hackney London Plumstead

Before that, in 1881, we can see Charlton's parents living at 4 Vine St., Lambeth, Surrey, England:
Charlton Jas. WYKES Head M Male 27 Erith, Kent, England Milkman
Eliza M. WYKES Wife M Female 21 Faversham, Kent, England

Charlton's mother's name was Eliza Maria CLEW. She married Charlton senior in q2/1879 at Poplar District, London, England. Charlton senior died in q1/1930 at Woolwich District, London, Middlesex, England.
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The 1911 census shows him living at 21 Bostall Hill, Plumstead, Kent, England, with his parents and brother:
Charlton Wykes Married M 58 Blacksmiths Hammerman Erith Kent
Eliza Wykes Wife Married (31 years) 49 London Islington
Charlton Wykes Son Single M 18 Electric Wire Worker Winnifred Canada
Edwin Wykes Son M 14 Bakers Boy and Student Bethnal Green London

I wonder if "Winnifred" is really "Winnipeg".
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I believe that Charlton and Dorothy lived with either Charlton's or Dorothy's parents after they married and until the early 1920's when they moved to 296 Wellhall Road, Eltham, London S.E.18. For a short time, they visited and stayed with Dorothy's brother Charles Knibbs at Bihorel, Rouen, France, returning to England in 1923.

I'm not 100% sure that I have the right birth date for Gladys.

Gladys was employed by Charlton Wykes as his housekeeper and as such, she, her husband Walter and daughter Evelyn lived in the house with Charlton before 1941. Shortley after her husband died, she married Charlton Wykes.

Gladys suffered from mental illness spending much of her later life in and out of institutions. She suffered from kleptomania and later chronic melancholia. Sadly, she died in a psychiatric hospital as it became impossible to care for her at home.